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(11)

EP 4 399 523 A1

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(43) Date of publication: 17.07.2024 Bulletin 2024/29 (21) Application number: 22868251.4 (22) Date of filing: 07.09.2022

(51) International Patent Classification (IPC):  G01N 33/52(2006.01) A61P 13/12(2006.01) A61K 38/22(2006.01) A61P 9/12(2006.01) (52) Cooperative Patent Classification (CPC): A61P 9/12; A61P 13/12; G01N 33/5041; G01N 2800/32; A61K 38/2242 (86) International application number: PCT/US2022/076008 (87) International publication number: WO 2023/039392 (16.03.2023 Gazette 2023/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.09.2021 US 202163241484 P (71) Applicant: Mayo Foundation for Medical Education and Research Rochester, Minnesota 55905 (US)	(72) Inventors: ZHENG, Ye Rochester, Minnesota 55901 (US) IYER, Seethalakshmi R. Rochester, Minnesota 55901 (US) BURNETT, John C., Jr. St. Anthony, Minnesota 55902 (US) SANGARALINGHAM, Sasantha J. Rochester, Minnesota 55902 (US) (74) Representative: Fish & Richardson P.C.  Highlight Business Towers Mies-van-der-Rohe-Straße 8 80807 München 80807 München (DE)