| (19) |
 |
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(11) |
EP 4 400 507 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
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13.11.2024 Bulletin 2024/46 |
| (43) |
Date of publication A2: |
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17.07.2024 Bulletin 2024/29 |
| (22) |
Date of filing: 08.09.2016 |
|
| (51) |
International Patent Classification (IPC):
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| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
08.09.2015 US 201562215339 P
|
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
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16844998.1 / 3347049 |
| (71) |
Applicant: Waters Technologies Corporation |
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Milford, MA 01757 (US) |
|
| (72) |
Inventor: |
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- Birdsall, Robert
Southborough MA 01772 (US)
|
| (74) |
Representative: Forresters IP LLP |
|
Skygarden
Erika-Mann-Straße 11
80636 München
80636 München (DE) |
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| |
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| (54) |
MULTIDIMENSIONAL CHROMATOGRAPHY METHOD FOR ANALYSIS OF ANTIBODY-DRUG CONJUGATES |
(57) The present disclosure relates to a sensitive, multidimensional chromatography method
for extraction, detection, and quantification of non-conjugated cytotoxic agents and
associated linker molecules used in cysteine based antibody-drug-conjugate production.