(19)
(11) EP 4 400 517 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
16.10.2024 Bulletin 2024/42

(43) Date of publication A2:
17.07.2024 Bulletin 2024/29

(21) Application number: 24172275.0

(22) Date of filing: 04.08.2016
(51) International Patent Classification (IPC): 
C07K 16/28(2006.01)
C07K 14/47(2006.01)
C07K 16/32(2006.01)
 C07K 14/74(2006.01)
C12N 5/0783(2010.01)
(52) Cooperative Patent Classification (CPC):
C07K 16/28; C07K 2317/622; C07K 2319/21; C07K 2319/33; C07K 16/2863; C07K 16/30; C07K 2317/94; C07K 2319/00; C07K 2319/03; A61P 31/12; A61P 35/00; C07K 14/7051; A61K 39/4613; A61K 39/464429; A61K 39/464406; A61K 39/4611; A61K 39/4631; A61K 39/464407
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 04.08.2015 US 201562200949 P

(62) Application number of the earlier application in accordance with Art. 76 EPC:
16754043.4 / 3331912

(71) Applicant: Xyphos Biosciences Inc.
South San Francisco, CA 94080 (US)

(72) Inventors:
  • LANDGRAF, Kyle
    Alameda, CA 94502-7956 (US)
  • STEIGER, Daniel, P.
    San Francisco, CA 94110 (US)
  • BARON, Tarah
    Hayward, CA 94544-4412 (US)
  • GEBHART, Dana
    San Francisco, CA 94117 (US)

(74) Representative: J A Kemp LLP 
80 Turnmill Street
London EC1M 5QU
London EC1M 5QU (GB)

   


(54) INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS, AND NON-NATURAL NKG2D LIGANDS THAT BIND NON-NATURAL NKG2D RECEPTORS


(57) This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified α1-α2 domains of NKG2D ligands.







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