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(11)

EP 4 401 769 A2

(12)

(88) Date of publication A3: 12.10.2023 (43) Date of publication: 24.07.2024 Bulletin 2024/30 (21) Application number: 22870656.0 (22) Date of filing: 15.09.2022

(51) International Patent Classification (IPC):  A61K 39/215(2006.01) C12N 7/00(2006.01) A61K 39/39(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/005; C12N 2770/20022; C12N 2770/20034; C12N 2740/16043; C12N 15/815; A61K 39/12; A61K 2039/55561; A61K 2039/55505; A61P 31/14 (86) International application number: PCT/US2022/043578 (87) International publication number: WO 2023/043868 (23.03.2023 Gazette 2023/12)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 16.09.2021 AR P210102579 (71) Applicants: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Buenos Aires, CP1425 (AR) Universidad De Buenos Aires (UBA) Ciudad Autónoma de Buenos Aires, C1053ABJ (AR) Inis Biotech LLC Kent County, DE 19963 (US)

(72) Inventors: IDROVO HIDALGO, Tommy 1193 Caba (AR) IBAÑEZ, Lorena Itati Caba, 1406 (AR) FERNANDEZ, Natalia Brenda Caba, 1407 (AR) SANTOS, Javier Tigre Buenos Aires, 1648 (AR) D'ALESSIO, Cecilia Caba, C1427DYE (AR) NADRA, Alejandro Daniel Caba, C1430 DUS (AR) PIGNATARO, Florencia Lanus Este (AR) (74) Representative: Torner, Juncosa I Associats, SL  C / Pau Claris, 108, 1r 1a 08009 Barcelona 08009 Barcelona (ES)