(19)
(11) EP 4 403 221 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
09.10.2024 Bulletin 2024/41

(43) Date of publication A2:
24.07.2024 Bulletin 2024/30

(21) Application number: 24169258.1

(22) Date of filing: 22.02.2008
(51) International Patent Classification (IPC): 
C07D 277/28(2006.01)
A61K 31/427(2006.01)
 C07D 417/14(2006.01)
A61P 31/12(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 31/426; A61K 31/427; A61K 31/496; A61K 31/5377; A61K 45/06; A61P 31/00; A61P 31/12; A61P 31/14; A61P 31/18; A61P 43/00
 
C-Sets:
  1. A61K 31/5377, A61K 2300/00;
  2. A61K 31/427, A61K 2300/00;
  3. A61K 31/426, A61K 2300/00;
  4. A61K 31/496, A61K 2300/00;
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

(30) Priority: 23.02.2007 US 90322807 P
06.07.2007 US 95871607 P

(62) Application number of the earlier application in accordance with Art. 76 EPC:
19219599.8 / 3689353
16180589.0 / 3150586
12167589.6 / 2487161
08743531.9 / 2118082

(71) Applicant: Gilead Sciences, Inc.
Foster City, CA 94404 (US)

(72) Inventors:
  • DESAI, Manoj, C.
    Pleasant Hill, 94523 (US)
  • HONG, Allen, Y.
    San Jose, 95129 (US)
  • HUI, Hon, C.
    San Mateo, 94401 (US)
  • LIU, Hongtao
    Cupertino, 95014 (US)
  • VIVIAN, Randall, W.
    San Mateo, 94404 (US)
  • XU, Lianhong
    Palo Alto, 94303 (US)

(74) Representative: Carpmaels & Ransford LLP 
One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)

   


(54) MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS


(57) The present application provides for a compound of Formula IV,

or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.





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