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(11)

EP 4 404 847 A1

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(43) Date of publication: 31.07.2024 Bulletin 2024/31 (21) Application number: 22873699.7 (22) Date of filing: 26.09.2022

(51) International Patent Classification (IPC):  A61B 8/08(2006.01) A61B 10/00(2006.01) A61B 5/00(2006.01) (52) Cooperative Patent Classification (CPC): A61N 7/00; A61B 8/0808; A61B 2010/0077; A61N 2007/0039; A61N 2007/0021; A61N 7/02; A61M 37/0092 (86) International application number: PCT/US2022/044718 (87) International publication number: WO 2023/049446 (30.03.2023 Gazette 2023/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 24.09.2021 US 202163247914 P (71) Applicant: Washington University St. Louis, Missouri 63130 (US)

(72) Inventors: CHEN, Hong St. Louis, Missouri 63130 (US) HU, Zhongtao St. Louis, Missouri 63130 (US) XU, Lu St. Louis, Missouri 63130 (US) PACIA, Christopher St. Louis, Missouri 63130 (US) CHIEN, Chih-Yen St. Louis, Missouri 63130 (US) LEUTHARDT, Eric St. Louis, Missouri 63130 (US) (74) Representative: Greaves Brewster LLP  Copa House Station Road Cheddar, Somerset BS27 3AH Cheddar, Somerset BS27 3AH (GB)