(19)
(11) EP 4 404 945 A2

(12)

(88) Date of publication A3:
12.10.2023

(43) Date of publication:
31.07.2024 Bulletin 2024/31

(21) Application number: 22873465.3

(22) Date of filing: 19.09.2022
(51) International Patent Classification (IPC): 
A61K 35/39(2015.01)
A61K 38/26(2006.01)
A61P 5/50(2006.01)
 A61P 3/10(2006.01)
A61K 38/28(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 35/39; C12N 5/0676; C12N 2533/54; A61P 3/10
(86) International application number:
PCT/US2022/044024
(87) International publication number:
WO 2023/049079 (30.03.2023 Gazette 2023/13)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 22.09.2021 US 202163247252 P
01.05.2022 US 202263337137 P

(71) Applicant: IMAGINE PHARMA, LLC
Pittsburgh, PA 15219 (US)

(72) Inventors:
  • THAI, Ngoc
    Pittsburgh PA 15232 (US)
  • POLLETT, Jonathan
    Pittsburgh, PA 15243 (US)
  • BOTTINO, Rita
    Pittsburgh, PA 15206 (US)
  • BOTTINO, Jonathan
    Pittsburgh, PA 15206 (US)

(74) Representative: HGF 
HGF Limited 1 City Walk
Leeds LS11 9DX
Leeds LS11 9DX (GB)

   


(54) COMPOSITIONS AND METHODS FOR PROPOGATING INSULIN AND GLUCAGON SECRETING CELLS FROM TYPE 1 DIABETIC PANCREATIC TISSUE AND THERAPEUTIC USES THEREOF