(19)

(11)

EP 4 405 461 A1

(12)

(43) Date of publication: 31.07.2024 Bulletin 2024/31 (21) Application number: 22873483.6 (22) Date of filing: 20.09.2022

(51) International Patent Classification (IPC):  C12N 5/00(2006.01) G01N 33/68(2006.01) A61B 17/43(2006.01) G01N 15/14(2024.01) A61D 19/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 5/0612; G01N 2333/42; G01N 2400/00 (86) International application number: PCT/US2022/044118 (87) International publication number: WO 2023/049112 (30.03.2023 Gazette 2023/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 21.09.2021 US 202117480402 21.09.2021 US 202117480322 (71) Applicant: Cytolutions, LLC Columbus, OH 43212 (US)	(72) Inventor: KRUG, Kristie Arlington, OH 43220 (US) (74) Representative: Kador & Partner Part mbB  Corneliusstraße 15 80469 München 80469 München (DE)