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EP 4 408 392 A1

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(43) Date of publication: 07.08.2024 Bulletin 2024/32 (21) Application number: 22797936.6 (22) Date of filing: 29.09.2022

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 47/42(2017.01) A61K 38/00(2006.01) A61K 47/02(2006.01) A61L 31/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 38/00; A61K 9/0024; A61K 47/42; A61K 47/02; A61K 31/704; A61P 35/00; C08J 3/075; C08J 2389/00; A61K 35/13 (86) International application number: PCT/US2022/045273 (87) International publication number: WO 2023/055963 (06.04.2023 Gazette 2023/14)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.09.2021 US 202163249949 P 30.09.2021 US 202163250441 P (71) Applicants: Boston Scientific Scimed, Inc. Maple Grove, MN 55311-1566 (US) Mayo Foundation for Medical Education and Research Rochester, Minnesota 55905 (US) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, CA 94607-5200 (US)

(72) Inventors: KIM, Hanjun Oakland, California 94607-5200 (US) XU, Chun Oakland, California 94607-5200 (US) JABBARZADEH, Ehsan Columbia, South Carolina 29201 (US) OKLU, Rahmi Rochester, Minnesota 55905 (US) KHADEMHOSSEINI, Alizera Oakland, California 94607-5200 (US) (74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB  Siebertstrasse 3 81675 München 81675 München (DE)