(19)
(11) EP 4 408 411 A2

(12)

(88) Date of publication A3:
11.05.2023

(43) Date of publication:
07.08.2024 Bulletin 2024/32

(21) Application number: 22877229.9

(22) Date of filing: 28.09.2022
(51) International Patent Classification (IPC): 
A61K 31/33(2006.01)
A61K 31/505(2006.01)
A61K 31/495(2006.01)
A61K 31/435(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 295/13; C07D 417/12; C07D 475/08; C07D 263/46; C07D 409/12; C07D 403/12; C07D 471/04; C07D 239/48; C07D 401/12; C07D 405/12; C07D 487/04; C07D 417/14; A61P 35/00; A61K 45/06
(86) International application number:
PCT/US2022/044974
(87) International publication number:
WO 2023/055763 (06.04.2023 Gazette 2023/14)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 30.09.2021 US 202163250803 P
26.09.2022 US 202217953221

(71) Applicant: The Regents of the University of Colorado, a body corporate
Denver, CO 80203 (US)

(72) Inventors:
  • LABARBERA, Daniel, V.
    Aurora, Colorado 80016 (US)
  • ABBOTT, Joshua, M.
    Silver Spring, Maryland 20902 (US)
  • ZHOU, Qiong
    Aurora, Colorado 80016 (US)
  • ESQUER, Hector
    Aurora, Colorado 80045 (US)
  • PRIGARO, Brett, Joseph
    Broomfield, Colorado 80023 (US)
  • AWOLADE, Paul
    Aurora, Colorado 80011 (US)

(74) Representative: Murgitroyd & Company 
165-169 Scotland Street
Glasgow G5 8PL
Glasgow G5 8PL (GB)

   


(54) SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER