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EP 4 412 629 A1

(12)

(43) Date of publication: 14.08.2024 Bulletin 2024/33 (21) Application number: 22879529.0 (22) Date of filing: 07.10.2022

(51) International Patent Classification (IPC):  A61K 35/32(2015.01) A61L 27/38(2006.01) A61L 27/36(2006.01) C12N 5/077(2010.01) (52) Cooperative Patent Classification (CPC): A61K 35/32; C12N 5/0655; C12N 2500/60; C12N 2527/00 (86) International application number: PCT/US2022/077782 (87) International publication number: WO 2023/060251 (13.04.2023 Gazette 2023/15)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 07.10.2021 US 202117496391 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, CA 94607-5200 (US)	(72) Inventors: ATHANASIOU, Kyriacos A. Irvine, CA 92697 (US) HU, Jerry C. Irvine, CA 92697 (US) BROWN, Wendy E. Irvine, CA 92697 (US) (74) Representative: Eyre, David Edward et al Schlich 9 St. Catherine's Road Littlehampton, West Sussex BN17 5HS Littlehampton, West Sussex BN17 5HS (GB)