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EP 4 416 302 A1

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(43) Date of publication: 21.08.2024 Bulletin 2024/34 (21) Application number: 21960804.9 (22) Date of filing: 15.10.2021

(51) International Patent Classification (IPC):  C12Q 1/6806(2018.01) C12Q 1/6855(2018.01) C12Q 1/6869(2018.01) C40B 30/04(2006.01) (52) Cooperative Patent Classification (CPC): C12Q 1/6855; C12N 15/1065   C-Sets: C12N 15/1065, C12Q 2525/191, C12Q 2563/179, C12Q 2521/501, C12Q 2531/10, C12Q 2563/149, C12Q 2533/101; C12Q 1/6855, C12Q 2521/531, C12Q 2563/179; (86) International application number: PCT/US2021/055174 (87) International publication number: WO 2023/063958 (20.04.2023 Gazette 2023/16)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (71) Applicant: Qiagen Sciences, LLC Germantown, MD 20874 (US)	(72) Inventors: LADER, Eric Boyds, Maryland 20841 (US) WU, Zhong Poolesville, Maryland 20837 (US) WANG, Yexun San Diego, California 92130 (US) PENG, Quan Clarksburg, Maryland 20871 (US) (74) Representative: König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB Düsseldorf  Mönchenwerther Straße 11 40545 Düsseldorf 40545 Düsseldorf (DE)