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(11)

EP 4 419 073 A1

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(43) Date of publication: 28.08.2024 Bulletin 2024/35 (21) Application number: 22797827.7 (22) Date of filing: 20.10.2022

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 31/00(2006.01) A61K 9/16(2006.01) A61P 31/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 9/0021; A61K 9/0024; A61K 9/1635; A61K 9/1652; A61K 9/1623; A61K 9/1617; A61K 9/0019; A61P 31/00; A61K 31/675; A61K 31/553 (86) International application number: PCT/GB2022/052684 (87) International publication number: WO 2023/067350 (27.04.2023 Gazette 2023/17)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 20.10.2021 GB 202115049 (71) Applicant: The University Of Liverpool Liverpool L69 7ZX (GB)

(72) Inventors: RANNARD, Steven Paul Liverpool Business Gateway 1st Floor, Block D, Waterhouse Building 3 Brownlow Street Liverpool, Merseyside L69 3GL (GB) OWEN, Andrew Liverpool Business Gateway 1st Floor, Block D, Waterhouse Building 3 Brownlow Street Liverpool, Merseyside L69 3GL (GB) HOBSON, James Liverpool Business Gateway 1st Floor, Block D, Waterhouse Building 3 Brownlow Street Liverpool, Merseyside L69 3GL (GB) SAVAGE, Alison Liverpool Business Gateway 1st Floor, Block D, Waterhouse Building 3 Brownlow Street Liverpool, Merseyside L69 3GL (GB) BARLOW, Eleanor Liverpool Business Gateway 1st Floor, Block D, Waterhouse Building 3 Brownlow Street Liverpool, Merseyside L69 3GL (GB) CURLEY, Paul Liverpool Business Gateway 1st Floor, Block D, Waterhouse Building 3 Brownlow Street Liverpool, Merseyside L69 3GL (GB) SHARP, Joanne Liverpool Business Gateway 1st Floor, Block D, Waterhouse Building 3 Brownlow Street Liverpool, Merseyside L69 3GL (GB) DONNELLY, Ryan Belfast Medical Biology Centre 97 Lisburn Road Belfast BT9 7BL (GB) ZHANG, Chunyang Belfast Medical Biology Centre 97 Lisburn Road Belfast BT9 7BL (GB) WU, Yu Belfast Medical Biology Centre 97 Lisburn Road Belfast BT9 7BL (GB) (74) Representative: Marks & Clerk LLP  15 Fetter Lane London EC4A 1BW London EC4A 1BW (GB)