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EP 4 419 543 A1

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(43) Date of publication: 28.08.2024 Bulletin 2024/35 (21) Application number: 22802559.9 (22) Date of filing: 11.10.2022

(51) International Patent Classification (IPC):  C07K 14/47(2006.01) C12N 5/10(2006.01) C12N 15/86(2006.01) C12N 9/12(2006.01) A61K 48/00(2006.01) C12N 15/10(2006.01) C07K 14/545(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/4746; C12N 15/102; C12N 2310/20; C12N 2750/14143; C12Q 2563/179; C07K 14/545; C12N 9/1205; C12N 15/86; C12N 5/0647; C07K 14/4702; A61K 35/28 (86) International application number: PCT/EP2022/078295 (87) International publication number: WO 2023/066735 (27.04.2023 Gazette 2023/17)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 19.10.2021 GB 202114972 (71) Applicants: Ospedale San Raffaele S.r.l. 20132 Milano (IT) Fondazione Telethon ETS 00185 Roma (IT)	(72) Inventors: DI MICCO, Rafaella 20132 Milan (IT) DELLA VOLPE, Lucrezia 20132 Milan (IT) CONTI, Anastasia 20132 Milan (IT) (74) Representative: D Young & Co LLP  3 Noble Street London EC2V 7BQ London EC2V 7BQ (GB)