(19)
(11) EP 4 419 682 A2

(12)

(88) Date of publication A3:
25.05.2023

(43) Date of publication:
28.08.2024 Bulletin 2024/35

(21) Application number: 22809279.7

(22) Date of filing: 21.10.2022
(51) International Patent Classification (IPC): 
C12N 15/113(2010.01)
A61K 31/713(2006.01)
A61K 31/712(2006.01)
A61P 1/16(2006.01)
 C12N 9/10(2006.01)
A61K 31/7115(2006.01)
A61K 31/7125(2006.01)
(52) Cooperative Patent Classification (CPC):
C12N 15/1137; A61K 31/713; A61K 31/7115; A61K 31/712; A61K 31/7125; A61P 1/16; C12N 2310/322; C12N 2310/321; C12N 2310/14; C12N 2310/315; C12N 2310/343; C12N 2310/351; C12N 2320/11; C12N 2320/32
 
C-Sets:
  1. C12N 2310/322, C12N 2310/3533;
  2. C12N 2310/321, C12N 2310/3521;
(86) International application number:
PCT/US2022/047491
(87) International publication number:
WO 2023/069754 (27.04.2023 Gazette 2023/17)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 22.10.2021 US 202163270813 P

(71) Applicant: Amgen Inc.
Thousand Oaks, CA 91320-1799 (US)

(72) Inventors:
  • RULIFSON, Ingrid
    Thousand Oaks, California 91320-1799 (US)
  • MEADE, Bryan
    Thousand Oaks, California 91320-1799 (US)
  • LONG, Jason C.
    Thousand Oaks, California 91320-1799 (US)
  • MURRAY, Justin K.
    Thousand Oaks, California 91320-1799 (US)

(74) Representative: J A Kemp LLP 
80 Turnmill Street
London EC1M 5QU
London EC1M 5QU (GB)

   


(54) RNAI CONSTRUCTS FOR INHIBITING GPAM EXPRESSION AND METHODS OF USE THEREOF