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EP 4 422 645 A2

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(88) Date of publication A3: 21.09.2023 (43) Date of publication: 04.09.2024 Bulletin 2024/36 (21) Application number: 22888111.6 (22) Date of filing: 26.10.2022

(51) International Patent Classification (IPC):  A61K 31/7125(2006.01) A61K 31/712(2006.01) C07H 21/02(2006.01) C07K 14/705(2006.01) A61K 31/7115(2006.01) A61K 48/00(2006.01) C07H 21/04(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/63; A61K 48/0016; A61K 48/0066; C12N 2310/321; C12N 15/1138; C12N 2310/11; C12N 2310/315; C12N 2320/34; C12N 2310/3341; C12N 2310/314   C-Sets: C12N 2310/321, C12N 2310/3521; C12N 2310/321, C12N 2310/3525; (86) International application number: PCT/US2022/047846 (87) International publication number: WO 2023/076352 (04.05.2023 Gazette 2023/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 27.10.2021 US 202163272612 P (71) Applicant: Wave Life Sciences Ltd. Singapore 018936 (SG)

(72) Inventors: BYRNE, Michael John Cambridge, Massachusetts 02138 (US) VATHIPADIEKAL, Vinod Cambridge, Massachusetts 02138 (US) IWAMOTO, Naoki Cambridge, Massachusetts 02138 (US) VARGEESE, Chandra Cambridge, Massachusetts 02138 (US) GUO, Lankai Cambridge, Massachusetts 02138 (US) HOSS, Andrew Guzior Cambridge, Massachusetts 02138 (US) (74) Representative: Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB  Ganghoferstraße 68 B 80339 München 80339 München (DE)