(19)

(11)

EP 4 422 651 A2

(12)

(88) Date of publication A3: 15.06.2023 (43) Date of publication: 04.09.2024 Bulletin 2024/36 (21) Application number: 22888415.1 (22) Date of filing: 24.10.2022

(51) International Patent Classification (IPC):  A61K 35/17(2015.01) A61P 35/00(2006.01) A61K 38/16(2006.01) C07H 21/04(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/4632; A61K 39/4611; A61K 39/464486; C07K 14/7051 (86) International application number: PCT/US2022/078597 (87) International publication number: WO 2023/076863 (04.05.2023 Gazette 2023/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 25.10.2021 US 202163271368 P 15.11.2021 US 202163279527 P (71) Applicant: Board Of Regents, The University Of Texas System Austin, TX 78701 (US)	(72) Inventors: YEE, Cassian Houston, Texas 77030 (US) PAN, Ke Houston, Texas 77030 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)