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EP 4 423 249 A1

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(43) Date of publication: 04.09.2024 Bulletin 2024/36 (21) Application number: 22830340.0 (22) Date of filing: 27.10.2022

(51) International Patent Classification (IPC):  C12N 5/0783(2010.01) A61P 35/00(2006.01) A61K 35/17(2015.01) A61P 35/02(2006.01) (52) Cooperative Patent Classification (CPC): C12N 5/0636; C12N 2500/05; C12N 2500/30; C12N 2501/2302; C12N 2501/2307; C12N 2501/2315; C12N 2500/14; C12N 2500/34; C12N 2500/38; C12N 2510/00; C12N 2501/2321; C12N 2527/00; C12N 2502/30; C12N 2501/515; C12N 2501/51; A61K 35/17; A61P 35/02 (86) International application number: PCT/US2022/078827 (87) International publication number: WO 2023/077034 (04.05.2023 Gazette 2023/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 28.10.2021 US 202163273138 P 25.05.2022 US 202263365326 P 14.10.2022 US 202263379632 P (71) Applicant: Lyell Immunopharma, Inc. South San Francisco, CA 94080 (US)

(72) Inventors: VODNALA, Suman Kumar San Francisco, California 94080 (US) PATEL, Yogin San Francisco, California 94080 (US) RESTIFO, Nicholas P. San Francisco, California 94080 (US) HARRIS, Benjamin San Francisco, California 94080 (US) (74) Representative: Maiwald GmbH  Elisenhof Elisenstraße 3 80335 München 80335 München (DE)