(19)

(11)

EP 4 430 408 A1

(12)

(43) Date of publication: 18.09.2024 Bulletin 2024/38 (21) Application number: 22893789.2 (22) Date of filing: 08.11.2022

(51) International Patent Classification (IPC):  G01N 35/08(2006.01) G01N 35/10(2006.01) G01N 15/14(2024.01) (52) Cooperative Patent Classification (CPC): G01N 15/1459; G01N 15/1434; G01N 2015/1438; G01N 2015/1452; G01N 15/1429; G01N 2015/1006; G01N 15/06; G01N 2015/0687; G01N 1/34; B03C 1/01; B03C 1/288; B03C 1/30; B03C 2201/18; B03C 2201/26; G01N 33/54333; G01N 15/075; G01N 15/149 (86) International application number: PCT/US2022/079493 (87) International publication number: WO 2023/086794 (19.05.2023 Gazette 2023/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 10.11.2021 US 202163263864 P (71) Applicant: University of Washington Seattle WA 98195 (US)	(72) Inventors: CHIU, Daniel T. Seattle, Washington 98105 (US) ZHAO, Mengxia Seattle, Washington 98105 (US) CHENG, Yuanhua Seattle, Washington 98105 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)