(19)
(11) EP 4 436 605 A1

(12)

(43) Date of publication:
02.10.2024 Bulletin 2024/40

(21) Application number: 22896787.3

(22) Date of filing: 18.11.2022
(51) International Patent Classification (IPC): 
A61K 39/44(2006.01)
A61K 47/64(2017.01)
A61P 35/00(2006.01)
C07K 14/315(2006.01)
 A61K 38/16(2006.01)
A61K 47/65(2017.01)
C07K 14/31(2006.01)
C07K 16/18(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 35/00; C07K 14/31; C07K 14/315; C07K 16/2887; C07K 16/2809; C07K 16/468; C07K 16/00; C07K 2317/31; C07K 16/2863; C07K 2317/622; C07K 2317/73; C07K 16/32; C07K 16/2803; C07K 2317/92; A61K 47/65; A61K 38/00
(86) International application number:
PCT/US2022/080197
(87) International publication number:
WO 2023/092106 (25.05.2023 Gazette 2023/21)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 22.11.2021 US 202117533071

(71) Applicant: The Trustees of The University of Pennsylvania
Philadelphia, PA 19104 (US)

(72) Inventors:
  • LINGHAN, Mei
    Urumqi, Xinjiang (CN)
  • ZAPPALA, Fabiana
    Philadelphia, Pennsylvania 19146 (US)
  • TSOURKAS, Andrew
    Bryn Mawr, Pennsylvania 19010 (US)

(74) Representative: Pearl Cohen Zedek Latzer Baratz UK LLP 
The Gridiron Building One Pancras Square
London N1C 4AG
London N1C 4AG (GB)

   


(54) RAPID PRODUCTION OF BISPECIFIC ANTIBODIES FROM OFF-THE-SHELF IGGS WITH HIGH YIELD AND PURITY