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(11)

EP 4 438 115 A3

(12)	EUROPEAN PATENT APPLICATION

(88) Date of publication A3: 08.01.2025 Bulletin 2025/02 (43) Date of publication A2: 02.10.2024 Bulletin 2024/40 (21) Application number: 24178429.7 (22) Date of filing: 04.09.2015

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) C12N 9/22(2006.01) C12N 15/85(2006.01) A61P 7/06(2006.01) C07K 14/805(2006.01) C12N 15/113(2010.01) C12N 15/867(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/805; C12N 9/22; C12N 15/86; C12N 2740/15043; C12N 2830/40; C12N 2740/16043; C12N 2830/15; C12N 2830/48; C12N 2830/50; A61K 48/0058; C12N 15/85; C12N 2830/008; C12N 2830/30; C12N 2830/46; A61K 48/0066; A61P 7/06

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 04.09.2014 US 201462045997 P (62) Application number of the earlier application in accordance with Art. 76 EPC: 19185730.9 / 3620521 15837740.8 / 3189143 (71) Applicants: Memorial Sloan-Kettering Cancer Center New York, NY 10065 (US) University of Washington Seattle, WA 98105-4721 (US)

(72) Inventors: SADELAIN, Michel New York, 10024 (US) RIVIERE, Isabelle New York, 10024 (US) MANSILLA-SOTO, Jorge Forest Hills, 11375 (US) WANG, Xiuyan New York, 10065 (US) STAMATOYANNOPOULOS, George Seattle, 98105 (US) STAMATOYANNOPOULOS, John Seattle, 98105 (US) LIU, Mingdong Seattle (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham B16 8QQ Birmingham B16 8QQ (GB)