(19)
(11) EP 4 440 546 A1

(12)

(43) Date of publication:
09.10.2024 Bulletin 2024/41

(21) Application number: 22847214.8

(22) Date of filing: 04.12.2022
(51) International Patent Classification (IPC): 
A61K 9/00(2006.01)
A61K 9/113(2006.01)
A61K 47/10(2017.01)
A61K 31/4155(2006.01)
A61P 17/00(2006.01)
A61P 17/10(2006.01)
A61P 17/14(2006.01)
 A61K 9/107(2006.01)
A61K 9/70(2006.01)
A61K 47/18(2017.01)
A61K 31/519(2006.01)
A61P 17/06(2006.01)
A61P 17/12(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 9/0014; A61K 47/18; A61K 9/7015; A61K 9/107; A61K 47/10; A61K 31/519; A61P 17/00; A61P 17/06; A61P 17/10; A61P 17/12; A61P 17/14; A61K 9/0017; A61K 9/113
(86) International application number:
PCT/US2022/080873
(87) International publication number:
WO 2023/102559 (08.06.2023 Gazette 2023/23)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 03.12.2021 US 202117541601
07.06.2022 US 202263365973 P

(71) Applicant: Incyte Corporation
Wilmington, DE 19803 (US)

(72) Inventors:
  • MODEPALLI, Naresh
    Wilmington, Delaware 19803 (US)
  • SHETH, Trupti
    Wilmington, Delaware 19803 (US)
  • BROWN, Marc
    Guildford, Surrey GU2 7AB (GB)
  • EVANS, Charles
    Guildford Surrey GU2 7AB (GB)
  • FIDGE, James
    Guildford, Surrey GU2 8GY (GB)
  • GUIDALI, Florencia
    Guildford, Surrey GU2 7AB (GB)
  • MCINTOSH, Tecashanell
    Guildford, Surrey GU2 7AB (GB)
  • COFRE, Vanessa
    Guildford, Surrey GU2 7AB (GB)

(74) Representative: Carpmaels & Ransford LLP 
One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)

   


(54) TOPICAL FORMULATIONS OF RUXOLITINIB WITH AN ORGANIC AMINE PH ADJUSTING AGENT FOR TREATMENT OF SKIN DISEASES