(19)
(11) EP 4 441 089 A1

(12)

(43) Date of publication:
09.10.2024 Bulletin 2024/41

(21) Application number: 22826075.8

(22) Date of filing: 30.11.2022
(51) International Patent Classification (IPC): 
C07K 14/805(2006.01)
C12N 5/078(2010.01)
C12N 15/90(2006.01)
 A61K 48/00(2006.01)
C12N 5/0789(2010.01)
C12N 5/074(2010.01)
(52) Cooperative Patent Classification (CPC):
C12N 15/907; C12N 5/0647; C07K 14/805; A61K 48/00; C12N 2510/00; C12N 2501/65
(86) International application number:
PCT/EP2022/083904
(87) International publication number:
WO 2023/099591 (08.06.2023 Gazette 2023/23)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 01.12.2021 EP 21306681

(71) Applicants:
  • INSERM (Institut National de la Santé et de la Recherche Médicale)
    75013 Paris (FR)
  • Assistance Publique-Hôpitaux de Paris (APHP)
    75004 Paris (FR)
  • Fondation Imagine
    75015 Paris (FR)
  • Université Paris Cité
    75006 Paris (FR)

(72) Inventors:
  • MICCIO, Annarita
    75015 Paris (FR)
  • ANTONIOU, Panagiotis
    75015 Paris (FR)

(74) Representative: Inserm Transfert 
PariSanté Campus 10 rue d'Oradour-sur-Glane
75015 Paris
75015 Paris (FR)

   


(54) METHODS FOR INCREASING FETAL HEMOGLOBIN CONTENT BY EDITING THE +55-KB REGION OF THE ERYTHROID-SPECIFIC BCL11A ENHANCER