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EP 4 444 334 A2

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(88) Date of publication A3: 24.08.2023 (43) Date of publication: 16.10.2024 Bulletin 2024/42 (21) Application number: 22905334.3 (22) Date of filing: 07.12.2022

(51) International Patent Classification (IPC):  A61K 35/768(2015.01) A61K 38/21(2006.01) C12N 5/0783(2010.01) A61K 35/17(2015.01) A61P 35/00(2006.01) C12N 15/86(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/14; C12N 15/86; A61K 35/761; C12N 2710/10332; C12N 2710/10343; C12N 7/00; C12N 5/0636; C12N 2510/00; C12N 2501/24; C12N 2501/52; A61K 35/17; A61P 35/00 (86) International application number: PCT/US2022/081090 (87) International publication number: WO 2023/108003 (15.06.2023 Gazette 2023/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 07.12.2021 US 202163286728 P (71) Applicants: Memgen, Inc. Houston, TX 77046 (US) H. Lee Moffitt Cancer Center And Research Institute, Inc. Tampa, FL 33612-9497 (US)

(72) Inventors: BEG, Amer, A. Tampa, FL 33612-9497 (US) CANTWELL, Mark, J. Houston, TX 77046 (US) (74) Representative: Lavoix  Bayerstraße 83 80335 München 80335 München (DE)