CELLS AND METHOD OF CELL CULTURE

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(11)

EP 4 446 338 A3

(12)	EUROPEAN PATENT APPLICATION

(88)	Date of publication A3:
	07.05.2025 Bulletin 2025/19

(43)	Date of publication A2:
	16.10.2024 Bulletin 2024/42

(21)	Application number: 24190440.8

(22)	Date of filing: 22.09.2016

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International Patent Classification (IPC):

C12P 21/00^(2006.01)
C07K 14/435^(2006.01)

C07K 16/00^(2006.01)

(52)	Cooperative Patent Classification (CPC):
	C07K 16/00; C12P 7/40; C12P 7/42; C12P 7/52; C12P 7/56; C12P 17/182; C12N 2500/32; C12N 2500/34; C12N 2510/00; C12N 2510/02; C12N 2511/00

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

23.09.2015 US 201562222555 P
19.09.2016 US 201662396475 P

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	16778886.8 / 3353313

(71)	Applicant: Pfizer Inc.
	New York, NY 10001-2192 (US)

(72)	Inventors:
	HILLER, Gregory Walter Wakefield, MA 01880 (US) MITCHELL, Jeffrey Joseph Nashua, NH 03064 (US) MULUKUTLA, Bhanu Chandra Lawrence, MA 01843 (US) PEGMAN, Pamela Mary Weston, MA 02493 (US)

(74)	Representative: Pfizer
	European Patent Department 23-25 avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)

(54)	CELLS AND METHOD OF CELL CULTURE

(57) The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in fed-batch culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.

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