(19)

(11)

EP 4 448 023 A1

(12)

(43) Date of publication: 23.10.2024 Bulletin 2024/43 (21) Application number: 22908180.7 (22) Date of filing: 20.10.2022

(51) International Patent Classification (IPC):  A61L 2/18(2006.01) A61L 101/36(2006.01) A61L 101/02(2006.01) A61L 101/46(2006.01) (52) Cooperative Patent Classification (CPC): A61L 2101/46; A01N 25/10; A01P 1/00   C-Sets: A01N 25/10, A01N 33/12; (86) International application number: PCT/US2022/047213 (87) International publication number: WO 2023/113919 (22.06.2023 Gazette 2023/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 14.12.2021 US 202163289241 P 19.10.2022 US 202217968886 (71) Applicant: HRL Laboratories, LLC Malibu, California 90265 (US)	(72) Inventors: GROSS, Adam Santa Monica, California 90405 (US) VAJO, John West Hills, California 91307 (US) GRAETZ, Jason Calabasas, California 91362 (US) (74) Representative: Coles, Andrea Birgit  Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)