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(11)

EP 4 448 763 A1

(12)

(43) Date of publication: 23.10.2024 Bulletin 2024/43 (21) Application number: 22840080.0 (22) Date of filing: 16.12.2022

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) (52) Cooperative Patent Classification (CPC): C12N 15/1137; C12Y 302/01045; C12N 2310/14 (86) International application number: PCT/EP2022/086504 (87) International publication number: WO 2023/111336 (22.06.2023 Gazette 2023/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 17.12.2021 EP 21215509 (71) Applicants: F. Hoffmann-La Roche AG 4070 Basel (CH) Genentech, Inc. South San Francisco, CA 94080-4990 (US)	(72) Inventors: BRAUN, Johannes 2970 Hørsolm (DK) CORDINER, Ross 2970 Hørsolm (DK) KIELPINSKI, Lukasz 2970 Hørsolm (DK) BINGOL, Baris South San Francisco, CA 94080-4990 (US) (74) Representative: Berendt, Frank Joachim Nathanael et al F. Hoffmann-La Roche AG Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)