(19)

(11)

EP 4 457 339 A1

(12)

(43) Date of publication: 06.11.2024 Bulletin 2024/45 (21) Application number: 22914650.1 (22) Date of filing: 26.12.2022

(51) International Patent Classification (IPC):  C12N 5/0783(2010.01) C07K 14/725(2006.01) C12N 15/90(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/705; C12N 9/22; C12N 15/907; A61K 39/464488; A61K 39/464468; A61K 39/464412; A61K 39/4631; A61K 39/4611; A61K 39/4632; A61K 39/464424; A61K 2239/28; A61K 39/464417; C12N 2310/20; C07K 2319/00 (86) International application number: PCT/CN2022/141874 (87) International publication number: WO 2023/125396 (06.07.2023 Gazette 2023/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 27.12.2021 WO PCT/CN2021/141667 (71) Applicant: Gracell Biotechnologies (Shanghai) Co., Ltd. Shanghai 200233 (CN)	(72) Inventors: ZHANG, Hua Shanghai 200233 (CN) SHI, Huan Shanghai 200233 (CN) SHEN, Lianjun Shanghai 200233 (CN) CAO, Wei Shanghai 200233 (CN) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)