(19)
(11) EP 4 457 347 A1

(12)

(43) Date of publication:
06.11.2024 Bulletin 2024/45

(21) Application number: 22917092.3

(22) Date of filing: 29.12.2022
(51) International Patent Classification (IPC): 
C12N 15/63(2006.01)
C12N 15/86(2006.01)
 C12N 15/85(2006.01)
C12N 15/90(2006.01)
(52) Cooperative Patent Classification (CPC):
C12N 15/86; C12N 2310/20; C12N 15/102; C12N 2740/16043; C12N 2740/15043; C12N 2830/008; C12N 2310/3519; C12N 15/1137; C12N 2320/34
(86) International application number:
PCT/TR2022/051691
(87) International publication number:
WO 2023/129095 (06.07.2023 Gazette 2023/27)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 31.12.2021 TR 202122284

(71) Applicant: T.C. Uskudar Universitesi
Istanbul (TR)

(72) Inventors:
  • AKGUL, Gorkem
    Buyukcekmece/Istanbul (TR)
  • AKYAR, Ali Dostcan
    Muratpasa/Antalya (TR)
  • YOLVER, Batuhan
    Serdivan/Sakarya (TR)
  • TASTAN, Cihan
    Uskudar/Istanbul (TR)

(74) Representative: Sevinç, Cenk 
Grup Ofis Marka Patent A.S. Atatürk Bulvari, 211/11 Kavaklidere
06680 Ankara
06680 Ankara (TR)

   


(54) CRISPR-PE SYSTEM FOR RETINOL DEHYDROGENASE 12 (RDH12) GENE MUTATIONS FOR USE IN THE TREATMENT OF RETINITIS PIGMENTOSA (RP) DISEASE