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(11)

EP 4 460 327 A1

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(43) Date of publication: 13.11.2024 Bulletin 2024/46 (21) Application number: 23737802.1 (22) Date of filing: 06.01.2023

(51) International Patent Classification (IPC):  A61K 39/25(2006.01) A61K 39/12(2006.01) C12N 7/04(2006.01) A61K 39/295(2006.01) C12N 15/869(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/12; C12N 2710/16743; C12N 2750/10034; C12N 2770/24334; A61K 2039/70; A61K 2039/543; C12N 2770/24371; C12N 2750/10071; A61K 2039/552; A61K 2039/575; C12N 15/86; C07K 14/005; C12N 2750/10022; C12N 2770/24322 (86) International application number: PCT/US2023/060270 (87) International publication number: WO 2023/133535 (13.07.2023 Gazette 2023/28)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 06.01.2022 US 202263297102 P (71) Applicant: The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Baton Rouge LA 70808 (US)

(72) Inventor: CHOWDHURY, Shafiqul Islam Baton Rouge, Louisiana 70816 (US) (74) Representative: Schlich  9 St Catherine's Road Littlehampton West Sussex BN17 5HS West Sussex BN17 5HS (GB)