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(11)

EP 4 460 329 A1

(12)

(43) Date of publication: 13.11.2024 Bulletin 2024/46 (21) Application number: 23700446.0 (22) Date of filing: 05.01.2023

(51) International Patent Classification (IPC):  A61K 47/58(2017.01) A61K 47/60(2017.01) A61K 47/69(2017.01) C12N 15/88(2006.01) A61K 47/59(2017.01) A61K 47/61(2017.01) A61K 48/00(2006.01) A61P 17/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 17/00; A61K 47/58; A61K 47/61; A61K 47/595; A61K 47/60; C12N 15/88; A61K 47/6933; A61K 47/6935; A61K 47/6939 (86) International application number: PCT/EP2023/050181 (87) International publication number: WO 2023/131648 (13.07.2023 Gazette 2023/28)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 05.01.2022 EP 22150378 (71) Applicant: Branca Bunus Limited 4 Dublin (IE)	(72) Inventors: WANG, Wenxin Dublin, 4 (IE) HE, Zhonglei Dublin, 4 (IE) A, Sigen Dublin, 4 (IE) LI, Yinghao Dublin, 4 (IE) LARA-SAEZ, Irene Dubln, 4 (IE) WANG, Xianqing Dublin, 4 (IE) TAI, Hongyun Dublin, 4 (IE) (74) Representative: Purdylucey Intellectual Property  6-7 Harcourt Terrace D02 FH73 Dublin 2 D02 FH73 Dublin 2 (IE)