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(11)

EP 4 463 543 A1

(12)

(43) Date of publication: 20.11.2024 Bulletin 2024/47 (21) Application number: 23700940.2 (22) Date of filing: 12.01.2023

(51) International Patent Classification (IPC):  C12N 9/10(2006.01) A61K 31/715(2006.01) C07H 3/06(2006.01) C08L 5/00(2006.01) A61K 31/702(2006.01) C12N 9/42(2006.01) C08B 37/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/2434; C12N 9/1051; C12Y 302/01008; C12Y 204/01; A61K 31/702; C07H 3/06; C08L 5/00; C08B 37/0057; A61P 31/04; A61P 35/00; A61P 3/10; A61P 9/00; C07H 3/04; C12P 19/00; C12P 19/04; C12P 19/12; C12P 19/18 (86) International application number: PCT/EP2023/050675 (87) International publication number: WO 2023/135229 (20.07.2023 Gazette 2023/29)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 13.01.2022 EP 22151474 (71) Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. 80539 München (DE)	(72) Inventors: PAUCHET, Yannick 07745 Jena (DE) SHIN, Na Ra 07745 Jena (DE) (74) Representative: Arth, Hans-Lothar  ABK Patent Attorneys Jasminweg 9 14052 Berlin 14052 Berlin (DE)