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(11)

EP 4 466 282 A2

(12)

(88) Date of publication A3: 21.09.2023 (43) Date of publication: 27.11.2024 Bulletin 2024/48 (21) Application number: 23743925.2 (22) Date of filing: 19.01.2023

(51) International Patent Classification (IPC):  C07K 14/715(2006.01) A61K 38/17(2006.01) C07K 14/47(2006.01) A61P 37/02(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/7151; C07K 14/70578; C12N 9/104; C07K 14/70521; C07K 14/70503; C07K 14/7051; A61K 39/4611; A61K 39/464482; A61K 39/463; C07K 2317/622; A61K 39/464429; A61K 39/464402; C12N 2740/15043; A61K 2239/27; A61K 2239/28; C07K 2317/24 (86) International application number: PCT/US2023/060937 (87) International publication number: WO 2023/141530 (27.07.2023 Gazette 2023/30)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 20.01.2022 US 202263301340 P 15.06.2022 US 202217807109 (71) Applicant: Instil Bio, Inc. Dallas, Texas 75219 (US)

(72) Inventors: BRIDGEMAN, John Manchester, Greater Manchester M13 9XX (GB) HAWKINS, Robert Manchester, Greater Manchester M13 9XX (GB) RODRIGUEZ, Ruben Dallas, Texas 75219 (US) KUEBERUWA, Gray Manchester, Greater Manchester M13 9XX (GB) KALAITSIDOU, Milena Dallas, Texas 75219 (US) KING, Michael Gavin Halifax, Yorkshire HX2 7JP (GB) (74) Representative: Murgitroyd & Company  165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)