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EP 4 469 177 A2

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(88) Date of publication A3: 05.10.2023 (43) Date of publication: 04.12.2024 Bulletin 2024/49 (21) Application number: 23710581.2 (22) Date of filing: 25.01.2023

(51) International Patent Classification (IPC):  B01D 15/36(2006.01) A61K 39/12(2006.01) C12N 7/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 7/00; B01D 15/363; A61K 39/12; A61P 31/14; Y02A 50/30; C12N 2770/24134; B01D 61/145 (86) International application number: PCT/US2023/061230 (87) International publication number: WO 2023/147337 (03.08.2023 Gazette 2023/31)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 25.01.2022 US 202263302910 P 25.01.2022 US 202263302920 P 29.11.2022 US 202263385274 P 29.11.2022 US 202263385309 P (71) Applicant: Takeda Vaccines, Inc. Cambridge, MA 02139 (US)

(72) Inventors: SANTANGELO, Joseph David Cambridge, Massachusetts 02139 (US) LIVENGOOD, Jill A. Cambridge, Massachusetts 02139 (US) LEE, Yockann Singapore 138567 (SG) LUO, Weiwen Singapore 138567 (SG) (74) Representative: Maiwald GmbH  Elisenhof Elisenstraße 3 80335 München 80335 München (DE)