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EP 4 472 963 A1

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(43) Date of publication: 11.12.2024 Bulletin 2024/50 (21) Application number: 23708960.2 (22) Date of filing: 01.02.2023

(51) International Patent Classification (IPC):  C07D 401/04(2006.01) C07D 519/00(2006.01) A61K 31/4365(2006.01) A61K 31/438(2006.01) A61K 31/496(2006.01) C07D 471/04(2006.01) A61P 35/00(2006.01) A61K 31/4375(2006.01) A61K 31/4545(2006.01) A61K 31/437(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07D 513/04; C07D 471/04; C07D 519/00; C07D 401/04 (86) International application number: PCT/US2023/012145 (87) International publication number: WO 2023/150186 (10.08.2023 Gazette 2023/32)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 01.02.2022 US 202263305668 P (71) Applicant: Arvinas Operations, Inc. New Haven, CT 06511 (US)	(72) Inventors: CALDWELL, John P. Ringwood, NJ 07456 (US) MEDINA, Jesus, Raul Gilbertsville, PA 19525 (US) MACALUSO, Jennifer Killingworth, CT 06419 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)