(19)

(11)

EP 4 475 869 A2

(12)

(88) Date of publication A3: 26.10.2023 (43) Date of publication: 18.12.2024 Bulletin 2024/51 (21) Application number: 23753684.2 (22) Date of filing: 10.02.2023

(51) International Patent Classification (IPC):  A61K 38/16(2006.01) C07K 14/00(2006.01) A61P 31/14(2006.01) (52) Cooperative Patent Classification (CPC): C07K 2319/70; C07K 16/10; C07K 2317/76; A61K 2039/55; A61K 2039/505 (86) International application number: PCT/US2023/062350 (87) International publication number: WO 2023/154841 (17.08.2023 Gazette 2023/33)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 11.02.2022 US 202263309147 P (71) Applicant: The Texas A&M University System College Station, TX 77840 (US)	(72) Inventors: CHEN, Zhilei College Station, TX 77873 (US) CHONIRA, Vikas College Station, TX 77843 (US) SIMEON, Rudo College Station, TX 77843 (US) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)