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EP 4 475 889 A1

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(43) Date of publication: 18.12.2024 Bulletin 2024/51 (21) Application number: 23706121.3 (22) Date of filing: 10.02.2023

(51) International Patent Classification (IPC):  A61K 47/14(2017.01) A61K 35/748(2015.01) A61K 39/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/748; A61K 9/5068; C12R 2001/01; C12P 21/02; C12N 15/74; C07K 14/195 (86) International application number: PCT/PT2023/050003 (87) International publication number: WO 2023/153949 (17.08.2023 Gazette 2023/33)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 10.02.2022 PT 2022117786 (71) Applicants: Instituto De Biologia Molecular E Celular - IBMC 4200-135 Porto (PT) Universidade Do Porto 4099-002 Porto (PT) CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental 4450-208 Matosinhos (PT)

(72) Inventors: NUNES DE OLIVEIRA, Paulo Miguel 4200-135 Porto (PT) FERREIRA MATINHA CARDOSO, Jorge Alexandre 4200-135 Porto (PT) DA SILVA LIMA, Steeve 4200-135 Porto (PT) DOS REIS SERRA, Cláudia Alexandra 4450-208 Matosinhos (PT) FERNANDES COUTINHO, Filipe 4450-208 Matosinhos (PT) PEREIRA DE OLIVA TELES, Aires Manuel 4450-208 Matosinhos (PT) (74) Representative: Ferreira Pinto, Francisca  Garrigues IP, Unipessoal Lda. Av. da República, 25-1° 1050-186 Lisboa 1050-186 Lisboa (PT)