2-((4-((S)-2-(4-CHLORO-2-FLUOROPHENYL)-2-METHYLBENZO[D][1,3]DIOXOL-4-YL)PIPERIDIN-1-YL)METHYL)-1-(((S)-OXETAN-2-YL)METHYL)-1H-IMIDAZOLE DERIVATIVES AS ACTIVATORS OF THE GLP1 RECEPTOR FOR THE TREATMENT OF OBESITY

(19)

(11)

EP 4 476 212 A1

(12)

(43)	Date of publication:
	18.12.2024 Bulletin 2024/51

(21)	Application number: 23705679.1

(22)	Date of filing: 10.02.2023

(51)

International Patent Classification (IPC):

C07D 405/14^(2006.01)
A61P 3/00^(2006.01)
A61P 3/06^(2006.01)
A61P 1/00^(2006.01)
A61P 9/00^(2006.01)
A61P 9/06^(2006.01)
A61P 9/12^(2006.01)
A61P 25/02^(2006.01)

A61K 31/4439^(2006.01)
A61P 3/04^(2006.01)
A61P 3/10^(2006.01)
A61P 1/16^(2006.01)
A61P 9/04^(2006.01)
A61P 9/10^(2006.01)
A61P 25/00^(2006.01)

(52)	Cooperative Patent Classification (CPC):
	C07D 405/14; A61P 3/00; A61P 3/04; A61P 3/06; A61P 3/10; A61P 1/00; A61P 1/16; A61P 9/00; A61P 9/04; A61P 9/06; A61P 9/10; A61P 9/12; A61P 25/00; A61P 25/02

(86)	International application number:
	PCT/IB2023/051207

(87)	International publication number:
	WO 2023/152698 (17.08.2023 Gazette 2023/33)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
	Designated Extension States:
	BA
	Designated Validation States:
	KH MA MD TN

(30)

Priority:

10.02.2022 US 202263308843 P
24.03.2022 US 202263323401 P
11.04.2022 WO PCT/IB2022/053367
07.10.2022 US 202263378749 P

(71)	Applicant: Novartis AG
	4056 Basel (CH)

(72)

Inventors:

(74)	Representative: Amodio, Eliana Lucia
	Novartis Pharma AG Patent Department Lichtstrasse 35 4056 Basel 4056 Basel (CH)

(54)	2-((4-((S)-2-(4-CHLORO-2-FLUOROPHENYL)-2-METHYLBENZO[D][1,3]DIOXOL-4-YL)PIPERIDIN-1-YL)METHYL)-1-(((S)-OXETAN-2-YL)METHYL)-1H-IMIDAZOLE DERIVATIVES AS ACTIVATORS OF THE GLP1 RECEPTOR FOR THE TREATMENT OF OBESITY