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EP 4 486 200 A1

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(43) Date of publication: 08.01.2025 Bulletin 2025/02 (21) Application number: 23781515.4 (22) Date of filing: 13.02.2023

(51) International Patent Classification (IPC):  A61B 5/00(2006.01) G01N 21/552(2014.01) G01N 33/58(2006.01) (52) Cooperative Patent Classification (CPC): G01N 21/554; G01N 33/54373; G01N 2201/0221 (86) International application number: PCT/TR2023/050133 (87) International publication number: WO 2023/191739 (05.10.2023 Gazette 2023/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 31.03.2022 TR 202205046 (71) Applicants: Istanbul Medipol Universitesi 34810 Beykoz/Istanbul (TR) Sabanci Universitesi Nanoteknoloji Arastirma Ve Uygulama Merkezi Tuzla/Istanbul (TR)

(72) Inventors: KURT, Hasan 34956 Beykoz/ Istanbul (TR) YUCE, Meral 34956 Beykoz/ Istanbul (TR) PEHLIVAN, Zeki Semih 34956 Beykoz/ Istanbul (TR) (74) Representative: Yalçiner Patent and Consulting Ltd.  Tunus Caddesi 85/3-4 Kavaklidere 06680 Ankara 06680 Ankara (TR)