(19)

(11)

EP 4 486 308 A1

(12)

(43) Date of publication: 08.01.2025 Bulletin 2025/02 (21) Application number: 23713555.3 (22) Date of filing: 01.03.2023

(51) International Patent Classification (IPC):  A61K 9/14(2006.01) A61P 35/00(2006.01) A61K 31/18(2006.01) (52) Cooperative Patent Classification (CPC): A61K 9/2027; A61K 9/146; A61P 35/00; A61K 31/18 (86) International application number: PCT/US2023/063520 (87) International publication number: WO 2023/168295 (07.09.2023 Gazette 2023/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 01.03.2022 US 202263268723 P (71) Applicant: Tvardi Therapeutics, Inc. Sugar Land, TX 77478 (US)	(72) Inventors: ALIBHAI, Imran Sugar Land, Texas 77478 (US) DE ACHAVAL, Sofia Sugar Land, Texas 77478 (US) CARICOFE, Ralph Raleigh, North Carolina 27609 (US) WHITESELL, JR., L. Graham Raleigh, North Carolina 27609 (US) SMART, Ian Raleigh, North Carolina 27609 (US) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)