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EP 4 486 362 A1

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(43) Date of publication: 08.01.2025 Bulletin 2025/02 (21) Application number: 22929235.4 (22) Date of filing: 04.03.2022

(51) International Patent Classification (IPC):  A61K 36/185(2006.01) A61P 3/04(2006.01) A61P 9/12(2006.01) A61K 127/00(2006.01) A61P 3/10(2006.01) (52) Cooperative Patent Classification (CPC): A61K 36/185; A61P 3/04; A61K 2236/39; A61K 2236/333 (86) International application number: PCT/BR2022/050072 (87) International publication number: WO 2023/164752 (07.09.2023 Gazette 2023/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (71) Applicant: CENTRO DE INOVAÇÃO E ENSAIOS PRÉ-CLÍNICOS 88.056-000 Florianópolis (BR)

(72) Inventors: BATISTA CALIXTO, João 88037-120 Florianópolis (BR) MARCON, Rodrigo 88025-320 Florianópolis (BR) SETIM FREITAS, Cristina 88054-550 Florianópolis (BR) LEMOS DE ANDRADE, Edinéia 88054-600 Florianópolis (BR) ÁUREA DOS SANTOS, Adara 88037-060 Florianópolis (BR) HELLER, Melina 88058-512 Florianópolis (BR) MACEDO JÚNIOR, Sérgio José 88058-565 Florianópolis (BR) MOTA SIQUEIRA JUNIOR, Jarbas 88034-102 Florianópolis (BR) (74) Representative: KATZAROV S.A.  Geneva Business Center 12 Avenue des Morgines 1213 Petit-Lancy 1213 Petit-Lancy (CH)