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(11)

EP 4 486 459 A1

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(43) Date of publication: 08.01.2025 Bulletin 2025/02 (21) Application number: 23713559.5 (22) Date of filing: 02.03.2023

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) A61K 39/395(2006.01) C07K 16/44(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/44; C07K 2317/56; A61K 2039/505; A61P 35/00; C07K 2317/92; C07K 2317/24 (86) International application number: PCT/US2023/063605 (87) International publication number: WO 2023/168352 (07.09.2023 Gazette 2023/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 03.03.2022 US 202263316338 P (71) Applicants: Yale University New Haven, CT 06405 (US) Gennao Bio, Inc. Pennington, NJ 08534 (US)	(72) Inventors: QUIJANO, Elias New Haven, CT 06510 (US) GLAZER, Peter New Haven, CT 06510 (US) SQUINTO, Stephen New York, NY 10021 (US) LUDWIG, Dale Pennington, NJ 08534 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)