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EP 4 486 889 A1

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(43) Date of publication: 08.01.2025 Bulletin 2025/02 (21) Application number: 23708802.6 (22) Date of filing: 06.03.2023

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 31/7088(2006.01) G01N 33/574(2006.01) C12N 9/02(2006.01) C12Q 1/26(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/1137; C12N 9/0051; C12Y 108/03005; A61K 31/7088; C12N 2310/20; C12N 2310/14; G01N 33/5011; G01N 33/5038; G01N 2800/52   C-Sets: C12N 2310/14, C12N 2310/531; (86) International application number: PCT/EP2023/055604 (87) International publication number: WO 2023/166226 (07.09.2023 Gazette 2023/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 04.03.2022 IT 202200004193 (71) Applicants: Istituto Europeo di Oncologia S.r.l. 20121 Milano (MI) (IT) Centro Cardiologico Monzino S.p.A. 20121 Milano (IT) Università degli Studi di Milano 20122 Milano (IT)

(72) Inventors: BANFI, Cristina 20121 Milano (MI) (IT) MINUCCI, Saverio 20121 Milano (MI) (IT) PALLAVICINI, Isabella 20121 Milano (MI) (IT) (74) Representative: Currado, Luisa et al De Simone & Partners S.r.l. Via Giulio Caccini, 1 00198 Roma 00198 Roma (IT)