(19)

(11)

EP 4 486 898 A2

(12)

(88) Date of publication A3: 19.10.2023 (43) Date of publication: 08.01.2025 Bulletin 2025/02 (21) Application number: 23763899.4 (22) Date of filing: 01.03.2023

(51) International Patent Classification (IPC):  C12N 15/70(2006.01) C07K 14/285(2006.01) A61K 35/74(2015.01) C12N 15/09(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/74; C12N 15/70; C12N 15/635; C07K 2317/569; C07K 16/2827; C07K 2317/76 (86) International application number: PCT/US2023/014290 (87) International publication number: WO 2023/167936 (07.09.2023 Gazette 2023/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 01.03.2022 US 202263315512 P (71) Applicant: University of Cincinnati Cincinnati, OH 45206 (US)	(72) Inventors: KOTAGIRI, Nalinikanth West Chester, Ohio 45069 (US) KHAROFA, Jordan Blue Ash, Ohio 45242 (US) KAMBLE, Nitin Cincinnati, Ohio 45220 (US) (74) Representative: Reddie & Grose LLP  The White Chapel Building 10 Whitechapel High Street London E1 8QS London E1 8QS (GB)