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EP 4 490 315 A1

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(43) Date of publication: 15.01.2025 Bulletin 2025/03 (21) Application number: 23716985.9 (22) Date of filing: 08.03.2023

(51) International Patent Classification (IPC):  C12Q 1/6816(2018.01) (52) Cooperative Patent Classification (CPC): C12Q 1/6816   C-Sets: C12Q 1/6816, C12Q 2525/173, C12Q 2531/113, C12Q 2535/122, C12Q 2537/143, C12Q 2563/107, C12Q 2563/149, C12Q 2563/159, C12Q 2563/179, C12Q 2565/519; (86) International application number: PCT/US2023/063980 (87) International publication number: WO 2023/172977 (14.09.2023 Gazette 2023/37)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 09.03.2022 US 202263318046 P 22.11.2022 US 202263384735 P (71) Applicant: Becton, Dickinson and Company Franklin Lakes, NJ 07417-1880 (US)

(72) Inventors: SHI, Xiaoshan San Jose, California 95131 (US) FAN, Wei San Jose, California 95131 (US) MEHRPOUYAN, Majid San Jose, California 95131 (US) WIDMANN-NGUYEN, Stephanie J. San Jose, California 95131 (US) TYZNIK, Aaron Jacob San Jose, California 95131 (US) CHEN, Yu San Jose, California 95131 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)