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(11)

EP 4 493 072 A1

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(43) Date of publication: 22.01.2025 Bulletin 2025/04 (21) Application number: 23718982.4 (22) Date of filing: 04.04.2023

(51) International Patent Classification (IPC):  A61B 8/10(2006.01) A61B 8/08(2006.01) A61B 8/00(2006.01) (52) Cooperative Patent Classification (CPC): A61B 8/10; A61B 8/4416; A61B 8/4455; A61B 8/4483; A61B 8/485 (86) International application number: PCT/EP2023/058901 (87) International publication number: WO 2023/194413 (12.10.2023 Gazette 2023/41)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 04.04.2022 EP 22382322 (71) Applicants: Consejo Superior De Investigaciones Científicas 28006 Madrid (ES) The University of Rochester Rochester, New York 14642 (US) University of Houston System Houston, Texas 77004 (US)

(72) Inventors: ZVIETCOVICH ZEGARRA, José Fernando 28006 Madrid (ES) MARCOS CELESTINO, Susana New York 14642 (US) LARIN, Kirill Houston, Texas 77004 (US) MONTERO DE ESPINOSA, Francisco 28006 Madrid (ES) (74) Representative: Flügel Preissner Schober Seidel  Patentanwälte PartG mbB Nymphenburger Straße 20 80335 München 80335 München (DE)