(19)

(11)

EP 4 493 151 A2

(12)

(88) Date of publication A3: 26.10.2023 (43) Date of publication: 22.01.2025 Bulletin 2025/04 (21) Application number: 23710760.2 (22) Date of filing: 14.03.2023

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 31/05(2006.01) A61K 31/192(2006.01) A61K 31/216(2006.01) A61K 31/4184(2006.01) A61K 31/44(2006.01) A61K 31/502(2006.01) A61K 31/553(2006.01) A61K 9/107(2006.01) A61K 31/12(2006.01) A61K 31/196(2006.01) A61K 31/4025(2006.01) A61K 31/436(2006.01) A61K 31/4453(2006.01) A61K 31/5377(2006.01) (52) Cooperative Patent Classification (CPC): A61K 9/145; A61K 9/148; A61K 9/5123; A61K 31/496; A61K 31/502; A61K 45/00 (86) International application number: PCT/EP2023/056506 (87) International publication number: WO 2023/174948 (21.09.2023 Gazette 2023/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 14.03.2022 US 202263269330 P 28.03.2022 WO PCT/EP2022/058180 (71) Applicant: TRX Biosciences Limited London EC4N 8AF (GB)	(72) Inventors: GOODING, Daniel London EC4N 8AF (GB) BREW, John London EC4N 8AF (GB) BANNISTER, Robin M. London EC4N 8AF (GB) (74) Representative: Schlich  9 St Catherine's Road Littlehampton West Sussex BN17 5HS West Sussex BN17 5HS (GB)