(19)

(11)

EP 4 493 166 A1

(12)

(43) Date of publication: 22.01.2025 Bulletin 2025/04 (21) Application number: 23716956.0 (22) Date of filing: 17.03.2023

(51) International Patent Classification (IPC):  A61K 31/00(2006.01) C07K 16/22(2006.01) A61K 39/395(2006.01) C07K 16/28(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2878; C07K 16/22; A61K 39/395; A61K 45/06; A61K 31/4245; A61K 31/198; A61K 31/663; A61K 31/7064; A61K 31/325   C-Sets: A61K 31/7064, A61K 2300/00; A61K 31/325, A61K 2300/00; A61K 39/395, A61K 2300/00; A61K 31/4245, A61K 2300/00; A61K 31/198, A61K 2300/00; A61K 31/663, A61K 2300/00; (86) International application number: PCT/US2023/015506 (87) International publication number: WO 2023/177870 (21.09.2023 Gazette 2023/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 18.03.2022 US 202263321205 P (71) Applicant: Baylor College of Medicine Houston, TX 77030 (US)	(72) Inventors: DECKER, William K. Houston, Texas 77030 (US) HALPERT, Matthew M. Houston, Texas 77030 (US) KONDURI, Vanaja Houston, Texas 77030 (US) (74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB  Siebertstrasse 3 81675 München 81675 München (DE)