(19)
(11) EP 4 493 222 A2

(12)

(88) Date of publication A3:
26.10.2023

(43) Date of publication:
22.01.2025 Bulletin 2025/04

(21) Application number: 23771648.5

(22) Date of filing: 15.03.2023
(51) International Patent Classification (IPC): 
A61K 47/54(2017.01)
A61K 47/64(2017.01)
 A61K 47/55(2017.01)
(52) Cooperative Patent Classification (CPC):
A61K 47/549; A61K 47/60
(86) International application number:
PCT/US2023/064470
(87) International publication number:
WO 2023/178202 (21.09.2023 Gazette 2023/38)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 15.03.2022 US 202217695645

(71) Applicant: Yale University
New Haven, CT 06510 (US)

(72) Inventors:
  • SPIEGEL, David
    New Haven, Connecticut 06511 (US)
  • CAIANIELLO, David
    New Haven, Connecticut 06511 (US)
  • ZHANG, Mengwen
    New Haven, Connecticut 06511 (US)

(74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB 
Leopoldstraße 4
80802 München
80802 München (DE)

   


(54) BIFUNCTIONAL SMALL MOLECULES TO TARGET THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS