(19)

(11)

EP 4 493 581 A1

(12)

(43) Date of publication: 22.01.2025 Bulletin 2025/04 (21) Application number: 23718569.9 (22) Date of filing: 17.02.2023

(51) International Patent Classification (IPC):  C07K 14/525(2006.01) C07D 487/04(2006.01) C12N 5/0783(2010.01) A61K 39/00(2006.01) C07D 519/00(2006.01) C12N 15/86(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2740/16043; C12N 2830/20; C07K 14/525; A61K 38/1841; A61K 39/4611; A61K 39/4631; A61K 39/46447; C07K 2319/03   C-Sets: A61K 38/1841, A61K 2300/00; (86) International application number: PCT/US2023/062804 (87) International publication number: WO 2023/177954 (21.09.2023 Gazette 2023/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 18.03.2022 US 202263269562 P (71) Applicant: University of Rochester Rochester, NY 14642 (US)	(72) Inventor: YAO, Zhenqiang Pittsford, NY 14534 (US) (74) Representative: Brand Murray Fuller LLP  50 Eastcastle Street London W1W 8EA London W1W 8EA (GB)